STKE: Specific Splice Signals
نویسندگان
چکیده
منابع مشابه
Characterization of human RNA splice signals by iterative functional selection of splice sites.
An iterative in vitro splicing strategy was employed to select for optimal 3' splicing signals from a pool of pre-mRNAs containing randomized regions. Selection of functional branchpoint sequences in HeLa cell nuclear extract yielded a sequence motif that evolved from UAA after one round of splicing toward a UACUAAC consensus after seven rounds. A significant part of the selected sequences cont...
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Receptor for Advanced Glycation Endproducts (RAGE), a transmembrane, multi-ligand, pattern recognition receptor, has been implicated in a range of inflammatory disease including diabetes, cancers, and cardiovascular disease (CVD) [1]. In addition to the full length receptor, soluble form of RAGE (sRAGE) has been shown to prevent the development of numerous pathologic states, and therefore highl...
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Splicing is one of the major contributors to observed spatiotemporal diversification of transcripts and proteins in metazoans. There are numerous factors that affect the process, but splice sites themselves along with the adjacent splicing signals are critical here. Unfortunately, there is still little known about splicing in plants and, consequently, further research in some fields of plant mo...
متن کاملClassification of RNA Splice Junctions Based on Genomic Signals
Classification of splice junctions is a critical component in the identification of new RNA isoforms in genetic annotations. Current high-throughput experimental techniques are unable to reliably identify splice junctions with high confidence. We propose to use a support vector machine (SVM) based model to improve the specificity of such experiments. Compared to existing schemes, our model perf...
متن کاملNeuroligin 1: A splice site-specific ligand for β-neurexins
Neurexins are neuronal cell surface proteins with hundreds of isoforms generated by alternative splicing. Here we describe neuroligin 1, a neuronal cell surface protein that is enriched in synaptic plasma membranes and acts as a splice site-specific ligand for p-neurexins. Neuroligin 1 binds to I~-neurexins only if they lack an insert in the alternatively spliced sequence of the G domain, but n...
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ژورنال
عنوان ژورنال: Science
سال: 2001
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.293.5533.1225c